Multidimensional Intersection of Nicotine, Gene Expression, and Behavior

The cholinergic system plays a crucial role in nervous function with important effects on developmental processes, cognition, attention, motivation, reward, learning, and memory. Nicotine, the reinforcing component of tobacco e-cigarettes, directly acts by targeting nicotinic acetylcholine receptors (nAChRs) brain. Activation nAChRs leads to multitude immediate long-lasting specific cellular populations, thereby affecting addictive properties drug. In addition direct actions nicotine binding opening nAChRs, subsequent activation circuits downstream signaling cascades wide range changes gene expression, which can subsequently alter further behavioral expression. this review, we provide an overview that lead expression highlight evidence supporting how these often be bidirectional, inducing behaviors associated drug intake.